Interleukin-8 in the Human Endometrium1
نویسندگان
چکیده
منابع مشابه
Interleukin-8 in the human endometrium.
We have previously shown that interleukin-8 (IL-8), a cytokine with neutrophil chemotactic/activating and T cell chemotactic activity, is produced by human endometrial stromal and glandular cells in culture. The present study investigated the temporal and spatial expression of IL-8 messenger ribonucleic acid (mRNA) and protein in the human endometrium. Endometrial tissue (n = 52) was obtained f...
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Background and Objective: Preterm birth occurs in 8% to 11% of all pregnancies and is responsible for 75% to 80% of all neonatal deaths. Cytokines may be involved in the etiology of preterm birth through their stimulation of prostaglandin synthesis. Cytokines may be released intocervicovaginal fluid during the breakdown of the chorio-decidual adhesion or from an inflammatory reactio...
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In highly purified human polymorphonuclear leukocyte (PMN) preparations containing less than 0.1% contaminating monocytes, significant amounts of interleukin-8 (IL-8) and small amounts of IL-la, IL-la, and tumor necrosis factoralpha (TNF-a) were produced by lipopolysaccharide (LPS) stimulation. Contrary to published reports, IL-6 production could not be detected. IL-10 inhibited the produc...
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In highly purified human polymorphonuclear leukocyte (PMN) preparations containing less than 0.1% contaminating monocytes, significant amounts of interleukin-8 (IL-8) and small amounts of IL-1 alpha, IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha) were produced by lipopolysaccharide (LPS) stimulation. Contrary to published reports, IL-6 production could not be detected. IL-10 inhibited t...
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The potential for the anti-hreast cancer drug tamoxifen [(Z)-l-[4-[2(dimethylamino)ethoxy]phenyl]-l,2-diphenyl-l-butenel to induce genotoxic damage (DNA adducts) in the human endometrium was investigated in vivo and in vitro. Endometria from hysterectomy patients who were not on tamoxifen were sectioned and maintained in short-term organ culture. The cultures were treated with either solvent ve...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1998
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.83.5.4754